The BRAF gene is frequently mutated in malignant melanoma.(SKIN CANCER FOUNDATION UPDATE): An article from: Journal of Drugs in Dermatology
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Citation Details
Title: The BRAF gene is frequently mutated in malignant melanoma.(SKIN CANCER FOUNDATION UPDATE)
Author: Michael R. Stratton
Publication: Journal of Drugs in Dermatology (Refereed)
Date: September 1, 2004
Publisher: Journal of Drugs in Dermatology, Inc.
Volume: 3 Issue: 5 Page: 573(3)
Distributed by Thomson Gale
The BRAF gene is frequently mutated in malignant melanoma.(SKIN CANCER FOUNDATION UPDATE): An article from: Journal of Drugs in Dermatology
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Computing Irregularity for Features in Medical Images: A Case Study of Malignant Melanoma, a skin cancer
The irregularity of a lesion border has been identified as the most significant factor in the diagnosis of malignant melanoma. The objective of the research was to find objective computable measures of contour irregularity and to apply them to skin lesions. A descriptive definition of irregularity was formulated which defines irregularity in terms of the five attributes: departure from a typical sequence (deviation), lack of obvious description, lack of compressibility, lack of symmetry and lack of a rule for generating a sequence. Methods based on the Hidden Markov Models, the Conditional Entropy, and a novel method based on Pattern Theory, were implemented, evaluated and tested. Their predictive power as classifiers of lesion abnormality was tested on 98 lesions. All methods showed sensitivity and specificity of over 0.7, with 0.82 scored for the Weibull based Hidden Markov Models. Ranking correlation between the computed measures and the human perception of the
Computing Irregularity for Features in Medical Images: A Case Study of Malignant Melanoma, a skin cancer
List Price: $ 102.00
Price: $ 101.99
Recognizing Early Symptoms of Melanoma Skin Cancer with the ABCDE Rule
Article by AntonCim
Before explaining the ?ABCDE Rule? lets make a quick overview of the melanoma skin cancer:
Melanoma is a malignant skin cancer that originates from the skin cells that produce melanin, the dark pigment that gives color to the skin. These cells are know as melanocytes from which this cancer is named.
Melanoma can occur in all areas of the human body where the melanocytes cells are normally present. It principally can be found in the skin but also in mucous membranes, in the meninges and in the eye.
These days we have a frequency of this cancer that is increasing in the population and it?s a little bit higher in females. The melanoma tumor tends to affect the adults with an age range varying from 35 to 65 years. Cases of melanoma within 30 years happen rarely.
According to the World Health Organization, each year in the world are diagnosed around 160,000 cases of malignant melanoma and the deaths connected to this disease are about 48,000 per year.
High rates of this skin tumor can be found in caucasian light-skinned people that live in sunny climate countries such as Australia, North America, Northern Europe and New Zealand.
Recognizing early signs of melanoma with the ABCDE rule:
The melanoma skin cancer develops on a clinically normal skin in the majority of patients. Since people usually do not develop new melanocytic moles or nevi in adult age, if this happens, the patient should consult his dermatologist as soon as possible for clinical evaluation of the new mole or nevus.
In other people melanomas originate from some pre-existent mole or nevus that evolves over time changing its color or shape. In these cases too, the patient should be aware and refer immediately to a specialized doctor.
Early symptoms of melanoma tumor are changes to the color, size, shape; bleeding or itching of existing moles or nevi; or the appearance of new lesions on the skin (in case of nodular melanoma).
These early signs or symptoms are summarized by the ?ABCDE rule?:
Asymmetry of the skin lesion.Borders: the lesion has irregular borders.Color: in most cases melanomas have many varied colors.Diameter: usually melanomas have a diameter greater than 6 mm.Enlarging: the lesion enlarges or evolves over time.
For detecting the melanoma skin cancer, visual diagnosis is commonly used even by health professionals nowadays and the ?ABCDE rule? is very important. It?s highly recommended to know what a melanoma tumor looks like, paying attention to suspicious lesions, moles or nevi and consulting a dermatologist without delay.
About the Author
Finally, if you are interested in more information about the melanoma skin cancer, please check out The Melanoma Skin Cancer website at http://themelanomaskincancer.com.
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